You're not just tired. Your cells are running out of fuel.
NAD+ is the coenzyme your mitochondria need to produce cellular energy, repair DNA, and maintain the signaling pathways that keep every system in your body functioning. By age 50, research suggests NAD+ levels may decline by more than half. Oral supplements have limited bioavailability. Your cells need the actual molecule.
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What NAD+ actually does — and why oral supplements fall short
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell. It is essential for mitochondrial energy production, DNA repair, and the cellular signaling pathways that regulate aging. Research suggests NAD+ levels decline naturally with age, and oral precursors like NMN and NR have limited bioavailability. Subcutaneous NAD+ delivers the actual molecule directly into your system.
Energy Production
NAD+ is a critical coenzyme in the mitochondrial electron transport chain. Without adequate NAD+, your cells cannot efficiently convert nutrients into ATP — the energy currency your body runs on. Declining NAD+ levels are associated with the fatigue, brain fog, and reduced physical capacity that many people experience with aging.
DNA Repair
NAD+ activates sirtuins and PARP enzymes — the molecular machinery responsible for detecting and repairing DNA damage. Every day, your cells sustain thousands of DNA lesions from oxidative stress, UV exposure, and normal metabolic activity. Research suggests that without sufficient NAD+, this repair process may slow, contributing to cellular aging. Many patients pair NAD+ with Sermorelin therapy to address both cellular repair and hormonal optimization simultaneously.
Cellular Signaling
NAD+ regulates key signaling pathways including sirtuins, CD38, and PARPs that influence inflammation, circadian rhythm, immune function, and metabolic homeostasis. When NAD+ levels drop, these pathways may become dysregulated — potentially contributing to chronic inflammation, disrupted sleep, and impaired immune response.
IV drips cost $1,500 per session. Oral supplements have limited absorption. There's a better way.
IV NAD+
- Pharmaceutical-grade NAD+
- High bioavailability
- 2–4 hour clinic visit per session
- Requires appointment and travel
- $750–$1,500 per session
- Often no ongoing physician oversight
Oral NMN / NR
- Convenient — just swallow a capsule
- Widely available
- Precursor, not actual NAD+
- Limited and variable bioavailability
- No physician oversight
- Unregulated supplement market
SubQ NAD+ (ElevateMD)
- Pharmaceutical-grade NAD+
- High bioavailability — bypasses GI tract
- Self-administer at home in 60 seconds
- 1,000mg per vial
- Board-certified physician oversight
- Licensed 503A compound pharmacy
- Delivered to your door
A structured clinical protocol. Not a prescription vending machine.
Every NAD+ protocol at ElevateMD follows a structured clinical framework — loading phase, maintenance, re-evaluation. Your physician designs your protocol based on your health history, monitors your progress, and adjusts dosing as needed.
Clinical Evaluation
Complete medical intake reviewed by a board-certified physician. Health history, current medications, goals, and contraindication screening.
Month 1: Loading Phase
Higher initial dosing to help restore depleted NAD+ levels. Your physician may recommend diagnostic lab panels to establish baseline biomarkers.
Month 2+: Maintenance
Ongoing monthly protocol to sustain elevated NAD+ levels. One vial per month, delivered automatically.
Month 3: Re-Evaluation
Physician check-in to assess progress, review any reported changes, and adjust protocol if needed. Optional follow-up labs.
Ongoing
Continuous physician monitoring. Protocol adjustments as needed. Automatic refills. No reorder required.
No hidden fees. No surprise charges. No insurance games.
Every price includes physician oversight, pharmacy compounding, and delivery. Optimize members save 25% on everything.
1 vial (1,000mg) per month. Physician oversight. Automatic refills. The standard maintenance protocol for most patients.
Get Started →3 vials (3,000mg) per quarter. Save vs. monthly pricing. Same physician oversight and automatic shipments.
Get Started →Single vial (1,000mg). No subscription. Includes physician evaluation and pharmacy compounding. Ideal for a trial month.
Get Started →Additional 1,000mg vial for existing patients during loading phase or for those who want to increase their monthly dosage.
Get Started →What's Included
- Board-certified physician clinical evaluation
- Pharmaceutical-grade NAD+ (1,000mg per vial, 100mg/mL x 10mL)
- Compounded by a licensed 503A compound pharmacy
- All supplies (syringes, alcohol swabs, sharps container)
- Injection guides and video tutorials
- Ongoing physician monitoring
- Direct shipping to your address
- Secure patient portal access
An IV NAD+ clinic charges $750–$1,500 per session for the same molecule. Over 3 months, that's $2,250–$4,500. ElevateMD's NAD+ Monthly protocol costs $897 for the same period — or $672 for Optimize members. Same pharmaceutical-grade NAD+, licensed pharmacy, physician oversight. No clinic visits required.
Want to save 25% on everything? Learn about Optimize membership.
NAD+ therapy may be appropriate if you identify with any of these.
You're exhausted — and it's not about sleep
You get 7–8 hours but still wake up drained. The fatigue isn't from poor sleep — it may be cellular. Your mitochondria need NAD+ to produce energy efficiently. No amount of coffee addresses a coenzyme deficiency.
You want to optimize performance
You train hard, eat well, and take care of yourself — but you've hit a plateau. NAD+ supports mitochondrial function, recovery, and the cellular machinery that underpins physical and cognitive performance. For comprehensive optimization, the Longevity Stack combines NAD+ with Sermorelin to target both cellular energy and growth hormone output.
You're proactive about aging
You understand that aging is a biological process driven by measurable cellular decline. NAD+ is one of the most well-studied molecules in longevity science. You'd rather address the biology now than manage symptoms later.
You don't have time for clinic visits
You've considered IV NAD+ but can't justify 2–4 hours in a clinic multiple times per month. Subcutaneous NAD+ takes 60 seconds, self-administered at home, and costs a fraction of what IV clinics charge.
A realistic timeline. No hype.
Every patient is different. This timeline reflects what many patients report during their NAD+ protocol. Individual results vary based on baseline NAD+ levels, age, lifestyle, and overall health.
Protocol Begins
You begin the loading phase with higher initial dosing. Your physician monitors your response and adjusts as needed. Some patients experience mild injection site redness or slight nausea, which typically resolves quickly.
Cellular Adaptation
As NAD+ levels begin to build, your physician may recommend baseline lab panels to track biomarker changes. Individual responses vary — your care team monitors your progress throughout.
Sustained Protocol
You transition to the maintenance phase. Your physician conducts a re-evaluation to assess progress and adjust dosing. Individual results vary — your physician tailors your protocol based on your response.
Individual results may vary. All therapies require physician evaluation.
Transparent about what to expect.
NAD+ subcutaneous injections are generally well-tolerated. Like any medical therapy, there are potential side effects you should be aware of. Your physician monitors your progress throughout your protocol.
Common & Typically Mild
- Injection site redness or mild soreness (resolves within hours)
- Slight nausea during loading phase (typically resolves within first few days)
- Mild flushing or warmth after injection
- Temporary lightheadedness (uncommon, usually related to injection speed)
Safety Measures
- Board-certified physician reviews every patient before prescribing
- Full medication and health history screening for contraindications
- Ongoing physician monitoring throughout your protocol
- Pharmaceutical-grade NAD+ from a licensed 503A compound pharmacy
- Detailed injection guides and video tutorials provided
- Direct physician access through your secure patient portal
Serious adverse effects from subcutaneous NAD+ are rare. Patients with certain medical conditions may not be appropriate candidates. Your ElevateMD physician will determine whether NAD+ therapy is right for you based on your complete clinical evaluation. Not every patient is approved.
From screening to delivery in 3 steps.
No phone calls, no waiting rooms, no insurance paperwork. Just a physician-directed protocol built for you.
Complete Your Screening
Fill out a 30-second eligibility form. If you're a potential candidate, you'll complete a secure clinical intake — your medical history, current medications, and health goals. Takes about 5 minutes.
Physician Review
Board-certified ElevateMD physicians review your complete intake within 24 hours. This is a real medical evaluation — not a rubber stamp. If you're not a good candidate, we'll tell you. If you are, your prescription is sent to our licensed compound pharmacy.
Protocol Delivered
Approved prescriptions ship from our licensed compound pharmacy directly to your address. Self-administer at home in 60 seconds. Your physician monitors your progress. Refills are automatic.
Frequently asked questions about NAD+ therapy.
How do I inject NAD+ SubQ?
NAD+ is administered as a subcutaneous injection — a small needle inserted just under the skin, typically in the abdomen or thigh. It takes about 60 seconds. We provide detailed injection guides, video tutorials, and your physician is available for questions. Most patients are comfortable self-injecting within the first week.
How quickly will I feel a difference?
Response timelines differ between patients. Your physician monitors your progress throughout treatment and adjusts your protocol based on your individual response. Results vary based on your baseline NAD+ levels, age, lifestyle, and overall health.
Is this the same NAD+ as IV clinics?
Yes. Our NAD+ is pharmaceutical-grade nicotinamide adenine dinucleotide, compounded by a licensed 503A pharmacy under physician prescription — the same molecule used in IV clinics. The difference is the delivery method: subcutaneous injection is self-administered at home in 60 seconds, versus a 2–4 hour IV drip at a clinic costing $750–$1,500 per session.
What's the difference between your NAD+ and oral NMN/NR supplements?
Oral NMN and NR are precursors that must be converted to NAD+ through multiple enzymatic steps in the body. Bioavailability is limited and variable. Our prescription NAD+ is the actual molecule, delivered via subcutaneous injection, bypassing the GI tract entirely. It is pharmaceutical-grade, physician-prescribed, and compounded by a licensed 503A pharmacy.
What are the side effects of NAD+ injections?
NAD+ subcutaneous injections are generally well-tolerated. Some patients may experience mild, temporary side effects including injection site redness, slight nausea, or flushing — particularly during the loading phase. These typically resolve within the first few days. Serious adverse effects are rare. Your physician monitors your progress and adjusts dosing as needed. If you experience any concerning symptoms, contact your ElevateMD physician through your secure patient portal.
Can I take NAD+ with other medications?
NAD+ is generally well-tolerated and has no known major drug interactions. However, your ElevateMD physician will review your complete medication list, medical history, and health goals during your clinical evaluation to ensure NAD+ therapy is appropriate for you. Always disclose all medications and supplements during your intake.
What if I'm not a good candidate?
If our physicians determine that NAD+ therapy is not appropriate for you based on your medical history or clinical evaluation, we will tell you directly. There is no charge for the eligibility screening, and you are under no obligation. We do not prescribe to patients who are not medically appropriate candidates.
Can I cancel anytime?
Yes. No contracts, no commitments. Subscription services can be paused or canceled anytime. To cancel, email [email protected].
Do you accept insurance?
No. ElevateMD is a cash-pay practice with transparent pricing. We do not accept insurance, and our therapies are not typically covered by insurance plans. This allows us to keep pricing straightforward and eliminate the administrative overhead that drives up costs at traditional clinics.
Many patients combine protocols for broader optimization.
NAD+ addresses cellular energy. These protocols target complementary mechanisms — hormonal optimization, integrated longevity, and diagnostic baselines — all managed by the same physician.
Sermorelin
Growth hormone-releasing hormone analog. Stimulates natural GH production during sleep. May support recovery, body composition, and sleep quality. Individual results vary.
The Longevity Stack
NAD+ and Sermorelin in one integrated protocol. Cellular energy during the day, hormonal optimization during sleep. Save $79/mo vs. purchasing separately.
Longevity Baseline Lab
Comprehensive biomarker panel designed for longevity patients. Establish your baseline before starting a protocol. Quest Diagnostics draw centers or at-home collection.
Every patient undergoes physician review before any prescription is issued.
All clinical decisions made by board-certified, U.S.-trained physicians.
HIPAA-compliant portal. Licensed 503A pharmacy fulfillment.
Find out if you qualify.
Free screening. No payment required. If you're approved, your NAD+ protocol ships from a licensed 503A compound pharmacy directly to your address.
If any of the above resonated with you, you may be a candidate for physician-directed therapy. Start with a free screening — no payment, no commitment.
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